Part4 Exploring Additional Medical Treatment
1 Consider taking sulfonylureas. These drugs lower the blood sugar by
inducing the pancreas to release more insulin that is needed to regulate the
blood sugar. The blood sugar levels lower at such a rapid rate they need to be
taken while you are eating to maintain insulin balance. This prevents you from
having a very low blood sugar level that can lead to hypoglycemia.
- An example of this hypoglycemic drug is tolbutamide, or
Diamol, with a dosage being between 500 and 3000 mg daily. It is available
in tablet form and can be used safely in those with renal diseases and in
the elderly.
- Another form is chlorpropamide, or Pamidine. The daily
dose of this drug, in tablet form, is up to 500 mg. Pamidine can cause
hyponatremia (low sodium concentration in the plasma), however.
- Second generations of this drug are as glibenclamide
(Daonil, one 5 mg tablet per day), gliclazide (Diamicron, one 80 mg tablet
per day); safe with renal disorders), glipizide (Mindiab, one 5 mg tablet
per day), and glimepiride (Amaryl, available in 1, 2, and 3 mg tablet
form).
- This drugs contain sulfa. If you're allergic, consider
other oral hypoglycemics. It should also be used with caution in those
with renal diseases and the elderly.
2 Try meglitinides. This drug works by increasing the
release of insulin from the pancreas. This variety acts within one hour after
being taken. They are usually given around half an hour before meals to reduce
the risk of the possibility of a hypoglycemic episode.
- This drug is used to reduce the sugar in the blood as
metabolism takes place. The dose is given as 500mg-1g once or twice a day
depending on the level of glucose in the patient’s blood.
3 Consider taking biguanides. These lower glucose absorption from the
gastrointestinal tract and the glucose production by the liver, and they also
work on enhancing insulin resistance and raising glucose anaerobic metabolism.
They are often used with sulfonyl urea as additional therapy in obese patients.
However, they have some side effects such as stomach upset and diarrhea and
patients with hepatic or renal disorders may develop lactic acidosis.
- Examples of biguanides are metformin (Glucophage,
available in 500 and 850 mg tablets) with a daily dose up to 2000 mg,
repaglinide (Novonorm, 0.5 or 1 mg taken before each meal), and
pioglitazone (Glustin, 15 / 30 mg once daily).
4 In severe cases, consider a pancreas
transplant. Pancreatic
transplant can be done where the patient has severe complications from
diabetes. This involves implanting a pancreas that is healthy – i.e. one that
is able to produce insulin regularly. This is only advised when all other
routes have been exhausted.
- This can be taken from a patient who has just passed on
or a partial pancreas that is from another person who is still alive.
- Your doctor will know if this is a treatment that could
be applicable to your situation. For most, insulin therapy and diet and
exercise will be enough to manage the condition.
Không có nhận xét nào:
Đăng nhận xét